Role of glutamate in neuron-glia metabolic coupling.

Détails

ID Serval
serval:BIB_CB58F139E432
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Role of glutamate in neuron-glia metabolic coupling.
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Magistretti P.J.
ISSN
1938-3207[electronic], 0002-9165[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
90
Numéro
3
Pages
875S-880S
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a central physiologic principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography. Approximately 10 y ago we provided experimental evidence that indicated a central role of glutamate signaling on astrocytes in neurometabolic coupling. The basic mechanism in neurometabolic coupling is the glutamate-stimulated aerobic glycolysis in astrocytes, such that the sodium-coupled reuptake of glutamate by astrocytes and the ensuing activation of the Na(+)-K(+) ATPase triggers glucose uptake and its glycolytic processing, which results in the release of lactate from astrocytes. Lactate can then contribute to the activity-dependent fueling of the neuronal energy demands associated with synaptic transmission. Analyses of this coupling have been extended in vivo and have defined the methods of coupling for inhibitory neurotransmission as well as its spatial extent in relation to the propagation of metabolic signals within the astrocytic syncytium. On the basis of a large body of experimental evidence, we proposed an operational model, "the astrocyte-neuron lactate shuttle." A series of results obtained by independent laboratories have provided further support for this model. This body of evidence provides a molecular and cellular basis for interpreting data that are obtained with functional brain imaging studies.
Mots-clé
Animals, Astrocytes/metabolism, Brain/metabolism, Brain/physiology, Glucose/metabolism, Glutamic Acid/metabolism, Glycolysis/physiology, Humans, Lactic Acid/metabolism, Mice, Models, Biological, Neurons/metabolism, Signal Transduction/physiology, Synaptic Transmission/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/02/2010 16:48
Dernière modification de la notice
20/08/2019 15:46
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