Klinische Bedeutung von Hepatitis-B-Virus-Mutanten. [Clinical significance of hepatitis B virus mutants]

Détails

ID Serval
serval:BIB_CB5610371F07
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Klinische Bedeutung von Hepatitis-B-Virus-Mutanten. [Clinical significance of hepatitis B virus mutants]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Moradpour  D., Blum  H. E.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
02/1998
Volume
87
Numéro
6
Pages
205-9
Notes
English Abstract
Journal Article
Review --- Old month value: Feb 4
Résumé
Hepatitis B virus (HBV) mutants have recently been identified in patients with acute or fulminant as well as chronic infections. Naturally occurring mutations have been identified in all viral genes and regulatory elements. Mutations in the gene coding for the hepatitis B surface antigen (HBsAg) may result in infection or viral persistence despite the presence of antibodies against HBsAg (anti-HBs) ("vaccine escape" or "immune escape"). Mutations in the gene encoding the pre-core/core protein (pre-core stop codon mutant) result in a loss of hepatitis B e antigen (HBeAg) and sero-conversion to antibodies to HBeAg (anti-HBe) with persistence of HBV replication (HBeAg minus mutant). Mutations in the core gene may lead among others to an immune escape due to a T cell receptor antagonism. Mutations in the polymerase gene can be associated with viral persistence or resistance to nucleoside analogues. Thus, HBV mutations may affect the natural course of infection, viral clearance and response to antiviral therapy. The exact contribution of specific mutations to diagnosis and therapy of HBV infection as well as patient management in clinical practice remain to be established.
Mots-clé
Disease Progression Hepatitis B/*virology Hepatitis B Antigens/genetics Hepatitis B virus/*genetics Humans *Mutation Prognosis
Pubmed
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 15:46
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