Klinische Bedeutung von Hepatitis-B-Virus-Mutanten. [Clinical significance of hepatitis B virus mutants]
Details
Serval ID
serval:BIB_CB5610371F07
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Klinische Bedeutung von Hepatitis-B-Virus-Mutanten. [Clinical significance of hepatitis B virus mutants]
Journal
Schweizerische Rundschau fur Medizin Praxis
ISSN
1013-2058 (Print)
Publication state
Published
Issued date
02/1998
Volume
87
Number
6
Pages
205-9
Notes
English Abstract
Journal Article
Review --- Old month value: Feb 4
Journal Article
Review --- Old month value: Feb 4
Abstract
Hepatitis B virus (HBV) mutants have recently been identified in patients with acute or fulminant as well as chronic infections. Naturally occurring mutations have been identified in all viral genes and regulatory elements. Mutations in the gene coding for the hepatitis B surface antigen (HBsAg) may result in infection or viral persistence despite the presence of antibodies against HBsAg (anti-HBs) ("vaccine escape" or "immune escape"). Mutations in the gene encoding the pre-core/core protein (pre-core stop codon mutant) result in a loss of hepatitis B e antigen (HBeAg) and sero-conversion to antibodies to HBeAg (anti-HBe) with persistence of HBV replication (HBeAg minus mutant). Mutations in the core gene may lead among others to an immune escape due to a T cell receptor antagonism. Mutations in the polymerase gene can be associated with viral persistence or resistance to nucleoside analogues. Thus, HBV mutations may affect the natural course of infection, viral clearance and response to antiviral therapy. The exact contribution of specific mutations to diagnosis and therapy of HBV infection as well as patient management in clinical practice remain to be established.
Keywords
Disease Progression
Hepatitis B/*virology
Hepatitis B Antigens/genetics
Hepatitis B virus/*genetics
Humans
*Mutation
Prognosis
Pubmed
Create date
25/01/2008 17:05
Last modification date
20/08/2019 16:46