Lipophilicity and its relationship with passive drug permeation.

Détails

ID Serval
serval:BIB_CA715AD71154
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Lipophilicity and its relationship with passive drug permeation.
Périodique
Pharmaceutical Research
Auteur(s)
Liu X., Testa B., Fahr A.
ISSN
1573-904X (Electronic)
ISSN-L
0724-8741
Statut éditorial
Publié
Date de publication
2011
Volume
28
Numéro
5
Pages
962-977
Langue
anglais
Résumé
In this review, we first summarize the structure and properties of biological membranes and the routes of passive drug transfer through physiological barriers. Lipophilicity is then introduced in terms of the intermolecular interactions it encodes. Finally, lipophilicity indices from isotropic solvent systems and from anisotropic membrane-like systems are discussed for their capacity to predict passive drug permeation across biological membranes such as the intestinal epithelium, the blood-brain barrier (BBB) or the skin. The broad evidence presented here shows that beyond the predictive power of lipophilicity parameters, the various intermolecular forces they encode allow a mechanistic interpretation of passive drug permeation.
Pubmed
Web of science
Création de la notice
06/05/2011 15:59
Dernière modification de la notice
20/08/2019 16:45
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