Lipophilicity and its relationship with passive drug permeation.
Details
Serval ID
serval:BIB_CA715AD71154
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lipophilicity and its relationship with passive drug permeation.
Journal
Pharmaceutical Research
ISSN
1573-904X (Electronic)
ISSN-L
0724-8741
Publication state
Published
Issued date
2011
Volume
28
Number
5
Pages
962-977
Language
english
Abstract
In this review, we first summarize the structure and properties of biological membranes and the routes of passive drug transfer through physiological barriers. Lipophilicity is then introduced in terms of the intermolecular interactions it encodes. Finally, lipophilicity indices from isotropic solvent systems and from anisotropic membrane-like systems are discussed for their capacity to predict passive drug permeation across biological membranes such as the intestinal epithelium, the blood-brain barrier (BBB) or the skin. The broad evidence presented here shows that beyond the predictive power of lipophilicity parameters, the various intermolecular forces they encode allow a mechanistic interpretation of passive drug permeation.
Pubmed
Web of science
Create date
06/05/2011 15:59
Last modification date
20/08/2019 16:45