The role of the NKG2D receptor for tumor immunity.

Détails

ID Serval
serval:BIB_C8E15B95143F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of the NKG2D receptor for tumor immunity.
Périodique
Seminars in cancer biology
Auteur(s)
Coudert J.D., Held W.
ISSN
1044-579X
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
16
Numéro
5
Pages
333-343
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Natural killer (NK) cells have originally been identified based on their capacity to kill transformed cells in a seemingly non-specific fashion. Over the last 15 years, knowledge on receptor ligand systems used by NK cells to specifically detect transformed cells has been accumulating rapidly. One of these receptor ligand systems, the NKG2D pathway, has received particular attention, and now serves as a paradigm for how the immune system is able to gather information about the health status of autologous host cells. In addition to its significance on NK cells, NKG2D, as well as other NK cell receptors, play significant roles on T cells. This review aims at summarizing recent insights into the regulation of NKG2D function, the control over NKG2D ligand expression and the role of NKG2D in tumor immunity. Finally, we will discuss first attempts to exploit NKG2D function to improve immunity to tumors.
Mots-clé
Animals, Humans, Immunity, Cellular/physiology, Immunologic Surveillance/physiology, Immunotherapy, Adoptive/methods, Ligands, Models, Biological, NK Cell Lectin-Like Receptor Subfamily K, Neoplasms/immunology, Neoplasms/therapy, Receptors, Immunologic/physiology, Receptors, Natural Killer Cell, Tumor Escape
Pubmed
Web of science
Création de la notice
17/01/2008 16:24
Dernière modification de la notice
20/08/2019 16:43
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