The role of the NKG2D receptor for tumor immunity.

Details

Serval ID
serval:BIB_C8E15B95143F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of the NKG2D receptor for tumor immunity.
Journal
Seminars in cancer biology
Author(s)
Coudert J.D., Held W.
ISSN
1044-579X
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
16
Number
5
Pages
333-343
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Natural killer (NK) cells have originally been identified based on their capacity to kill transformed cells in a seemingly non-specific fashion. Over the last 15 years, knowledge on receptor ligand systems used by NK cells to specifically detect transformed cells has been accumulating rapidly. One of these receptor ligand systems, the NKG2D pathway, has received particular attention, and now serves as a paradigm for how the immune system is able to gather information about the health status of autologous host cells. In addition to its significance on NK cells, NKG2D, as well as other NK cell receptors, play significant roles on T cells. This review aims at summarizing recent insights into the regulation of NKG2D function, the control over NKG2D ligand expression and the role of NKG2D in tumor immunity. Finally, we will discuss first attempts to exploit NKG2D function to improve immunity to tumors.
Keywords
Animals, Humans, Immunity, Cellular/physiology, Immunologic Surveillance/physiology, Immunotherapy, Adoptive/methods, Ligands, Models, Biological, NK Cell Lectin-Like Receptor Subfamily K, Neoplasms/immunology, Neoplasms/therapy, Receptors, Immunologic/physiology, Receptors, Natural Killer Cell, Tumor Escape
Pubmed
Web of science
Create date
17/01/2008 16:24
Last modification date
20/08/2019 16:43
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