Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.

Détails

ID Serval
serval:BIB_C8B0D64C472A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.
Périodique
Life Sciences
Auteur(s)
Schedel J.M., Tanaka H., Kiyonaga A., Shindo M., Schutz Y.
ISSN
0024-3205 (Print)
ISSN-L
0024-3205
Statut éditorial
Publié
Date de publication
10/1999
Volume
65
Numéro
23
Pages
2463-2470
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response to Cr ingestion a large rise in serum Cr concentration was observed (by 50 folds) occurring approximately 2 1/2h after the ingestion (peak value of 2.17 +/- 0.66 mmol x l(-1)). We also found a moderate but significant rise in serum Crn concentration averaging 13 % after 3 h (peak value at 99.5 +/- 10.5 micromol x l(-1)). A dose response curve obtained in two case studies, in whom different doses of Cr were ingested (0, 2.5, 5, 10, 15, 20 g and 0, 10, 20, 30 g), showed that serum Cr concentration as well as the peak time increased linearly with Cr ingestion. In addition, acute Crn ingestion (5 g) resulted in a substantial increase in serum Crn concentration (by 10 folds) but led to a minor rise in serum Cr concentration (by 2 folds). These results suggest that when acute doses of Cr are ingested in humans, the degree of conversion of exogenous Cr to Crn in the stomach and the gut can be considered as negligible following the first 6 h of ingestion. However, further studies are required to explore the prolonged effect of Cr on Crn metabolism.
Mots-clé
Administration, Oral, Adult, Anaerobiosis, Creatine/administration & dosage, Creatine/blood, Creatinine/blood, Dietary Supplements, Dose-Response Relationship, Drug, Drug Administration Schedule, Energy Metabolism/drug effects, Female, Humans, Individuality, Male
Pubmed
Web of science
Création de la notice
21/01/2008 14:07
Dernière modification de la notice
20/08/2019 16:43
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