Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.

Details

Serval ID
serval:BIB_C8B0D64C472A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.
Journal
Life Sciences
Author(s)
Schedel J.M., Tanaka H., Kiyonaga A., Shindo M., Schutz Y.
ISSN
0024-3205 (Print)
ISSN-L
0024-3205
Publication state
Published
Issued date
10/1999
Volume
65
Number
23
Pages
2463-2470
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response to Cr ingestion a large rise in serum Cr concentration was observed (by 50 folds) occurring approximately 2 1/2h after the ingestion (peak value of 2.17 +/- 0.66 mmol x l(-1)). We also found a moderate but significant rise in serum Crn concentration averaging 13 % after 3 h (peak value at 99.5 +/- 10.5 micromol x l(-1)). A dose response curve obtained in two case studies, in whom different doses of Cr were ingested (0, 2.5, 5, 10, 15, 20 g and 0, 10, 20, 30 g), showed that serum Cr concentration as well as the peak time increased linearly with Cr ingestion. In addition, acute Crn ingestion (5 g) resulted in a substantial increase in serum Crn concentration (by 10 folds) but led to a minor rise in serum Cr concentration (by 2 folds). These results suggest that when acute doses of Cr are ingested in humans, the degree of conversion of exogenous Cr to Crn in the stomach and the gut can be considered as negligible following the first 6 h of ingestion. However, further studies are required to explore the prolonged effect of Cr on Crn metabolism.
Keywords
Administration, Oral, Adult, Anaerobiosis, Creatine/administration & dosage, Creatine/blood, Creatinine/blood, Dietary Supplements, Dose-Response Relationship, Drug, Drug Administration Schedule, Energy Metabolism/drug effects, Female, Humans, Individuality, Male
Pubmed
Web of science
Create date
21/01/2008 13:07
Last modification date
20/08/2019 15:43
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