Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C892A237D914
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.
Périodique
Viruses
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Statut éditorial
Publié
Date de publication
15/09/2023
Peer-reviewed
Oui
Volume
15
Numéro
9
Pages
1926
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
While an important part of the world's population is vaccinated against SARS-CoV-2, new variants continue to emerge. We observe that even after a fifth dose of the mRNA bivalent vaccine, most vaccinated individuals have antibodies that poorly neutralize several Omicron subvariants, including BQ.1.1, XBB, XBB.1.5, FD.1.1, and CH.1.1. However, Fc-effector functions remain strong and stable over time against new variants, which may partially explain why vaccines continue to be effective. We also observe that donors who have been recently infected have stronger antibody functional activities, including neutralization and Fc-effector functions, supporting the observations that hybrid immunity leads to better humoral responses.
Mots-clé
Humans, SARS-CoV-2/genetics, COVID-19/prevention & control, Antibodies, Vaccines, Combined, RNA, Messenger/genetics, ADCC, COVID-19, SARS-CoV-2, coronavirus, hybrid immunity, neutralization, omicron variants, spike glycoproteins
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2023 14:56
Dernière modification de la notice
25/01/2024 8:44