Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C892A237D914
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.
Journal
Viruses
Author(s)
Tauzin A., Beaudoin-Bussières G., Benlarbi M., Nayrac M., Bo Y., Gendron-Lepage G., Medjahed H., Perreault J., Gokool L., Arlotto P., Morrisseau C., Tremblay C., Kaufmann D.E., Martel-Laferrière V., Levade I., Côté M., Bazin R., Finzi A.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
15/09/2023
Peer-reviewed
Oui
Volume
15
Number
9
Pages
1926
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
While an important part of the world's population is vaccinated against SARS-CoV-2, new variants continue to emerge. We observe that even after a fifth dose of the mRNA bivalent vaccine, most vaccinated individuals have antibodies that poorly neutralize several Omicron subvariants, including BQ.1.1, XBB, XBB.1.5, FD.1.1, and CH.1.1. However, Fc-effector functions remain strong and stable over time against new variants, which may partially explain why vaccines continue to be effective. We also observe that donors who have been recently infected have stronger antibody functional activities, including neutralization and Fc-effector functions, supporting the observations that hybrid immunity leads to better humoral responses.
Keywords
Humans, SARS-CoV-2/genetics, COVID-19/prevention & control, Antibodies, Vaccines, Combined, RNA, Messenger/genetics, ADCC, COVID-19, SARS-CoV-2, coronavirus, hybrid immunity, neutralization, omicron variants, spike glycoproteins
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2023 14:56
Last modification date
25/01/2024 8:44
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