La polypose adenomateuse familiale. [Familial adenomatous polyposis]

Détails

ID Serval
serval:BIB_C885504C4D01
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
La polypose adenomateuse familiale. [Familial adenomatous polyposis]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur⸱e⸱s
Constanda  M. T., Munier  F. L., Caplin  S., Givel  J. C.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
08/1996
Volume
85
Numéro
35
Pages
1052-7
Notes
English Abstract
Journal Article
Review --- Old month value: Aug 27
Résumé
Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the development of numerous adenomatous polyps in the colon and rectum with diverse extracolonic manifestations. Recent genetic advances have lead to the sequencing of the FAP gene, with important implications for screening, diagnosis and follow-up. Appropriate management of probands and at-risk patients is of the utmost importance, as untreated carriers will develop colorectal cancer. Identification of FAP families and tracing of pedigrees represent the most important steps. To this end registries are essential, allowing a comprehensive multidisciplinary approach. They have justified their place by decreasing related morbidity and mortality. An overview and discussion of clinical features and management are presented.
Mots-clé
Adenomatous Polyposis Coli/diagnosis/*genetics/prevention & control/therapy Genes, Dominant Heterozygote Detection Humans Neoplasms, Multiple Primary/genetics Pedigree Registries
Pubmed
Création de la notice
28/01/2008 12:53
Dernière modification de la notice
20/08/2019 15:43
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