La polypose adenomateuse familiale. [Familial adenomatous polyposis]

Details

Serval ID
serval:BIB_C885504C4D01
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
La polypose adenomateuse familiale. [Familial adenomatous polyposis]
Journal
Schweizerische Rundschau fur Medizin Praxis
Author(s)
Constanda  M. T., Munier  F. L., Caplin  S., Givel  J. C.
ISSN
1013-2058 (Print)
Publication state
Published
Issued date
08/1996
Volume
85
Number
35
Pages
1052-7
Notes
English Abstract
Journal Article
Review --- Old month value: Aug 27
Abstract
Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the development of numerous adenomatous polyps in the colon and rectum with diverse extracolonic manifestations. Recent genetic advances have lead to the sequencing of the FAP gene, with important implications for screening, diagnosis and follow-up. Appropriate management of probands and at-risk patients is of the utmost importance, as untreated carriers will develop colorectal cancer. Identification of FAP families and tracing of pedigrees represent the most important steps. To this end registries are essential, allowing a comprehensive multidisciplinary approach. They have justified their place by decreasing related morbidity and mortality. An overview and discussion of clinical features and management are presented.
Keywords
Adenomatous Polyposis Coli/diagnosis/*genetics/prevention & control/therapy Genes, Dominant Heterozygote Detection Humans Neoplasms, Multiple Primary/genetics Pedigree Registries
Pubmed
Create date
28/01/2008 12:53
Last modification date
20/08/2019 15:43
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