Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.
Détails
Télécharger: 38727320_BIB_C7F3B02D46B1.pdf (1525.34 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C7F3B02D46B1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.
Périodique
Cells
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Statut éditorial
Publié
Date de publication
04/05/2024
Peer-reviewed
Oui
Volume
13
Numéro
9
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in physiological states such as exercise, fasting, and extended starvation, are avidly taken up and used by the brain. Both the ketogenic diet and exogenous ketone supplementation have been associated with neuroprotective effects across a spectrum of conditions. These include refractory epilepsy, neurodegenerative disorders, cognitive impairment, focal cerebral ischemia, and traumatic brain injuries. Beyond this, ketone bodies possess a plethora of attributes that appear to be particularly favourable after cardiac arrest. These encompass anti-inflammatory effects, the attenuation of oxidative stress, the improvement of mitochondrial function, a glucose-sparing effect, and the enhancement of cardiac function. The aim of this manuscript is to appraise pertinent scientific literature on the topic through a narrative review. We aim to encapsulate the existing evidence and underscore the potential therapeutic value of ketone bodies in the context of cardiac arrest to provide a rationale for their use in forthcoming translational research efforts.
Mots-clé
Ketone Bodies/metabolism, Humans, Heart Arrest/metabolism, Animals, Diet, Ketogenic, anoxic brain injury, cerebral metabolism, heart arrest, ischemia–reperfusion, ketone bodies
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/05/2024 13:32
Dernière modification de la notice
09/08/2024 15:06