Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.
Details
Serval ID
serval:BIB_C7F3B02D46B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use.
Journal
Cells
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Publication state
Published
Issued date
04/05/2024
Peer-reviewed
Oui
Volume
13
Number
9
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in physiological states such as exercise, fasting, and extended starvation, are avidly taken up and used by the brain. Both the ketogenic diet and exogenous ketone supplementation have been associated with neuroprotective effects across a spectrum of conditions. These include refractory epilepsy, neurodegenerative disorders, cognitive impairment, focal cerebral ischemia, and traumatic brain injuries. Beyond this, ketone bodies possess a plethora of attributes that appear to be particularly favourable after cardiac arrest. These encompass anti-inflammatory effects, the attenuation of oxidative stress, the improvement of mitochondrial function, a glucose-sparing effect, and the enhancement of cardiac function. The aim of this manuscript is to appraise pertinent scientific literature on the topic through a narrative review. We aim to encapsulate the existing evidence and underscore the potential therapeutic value of ketone bodies in the context of cardiac arrest to provide a rationale for their use in forthcoming translational research efforts.
Keywords
Ketone Bodies/metabolism, Humans, Heart Arrest/metabolism, Animals, Diet, Ketogenic, anoxic brain injury, cerebral metabolism, heart arrest, ischemia–reperfusion, ketone bodies
Pubmed
Web of science
Open Access
Yes
Create date
13/05/2024 13:32
Last modification date
09/08/2024 15:06