Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_C5DF47ED60E0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Titre
Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.
Périodique
Science
Auteur⸱e⸱s
Bartholomay L.C., Waterhouse R.M., Mayhew G.F., Campbell C.L., Michel K., Zou Z., Ramirez J.L., Das S., Alvarez K., Arensburger P., Bryant B., Chapman S.B., Dong Y., Erickson S.M., Karunaratne S.H., Kokoza V., Kodira C.D., Pignatelli P., Shin S.W., Vanlandingham D.L., Atkinson P.W., Birren B., Christophides G.K., Clem R.J., Hemingway J., Higgs S., Megy K., Ranson H., Zdobnov E.M., Raikhel A.S., Christensen B.M., Dimopoulos G., Muskavitch M.A.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
330
Numéro
6000
Pages
88-90
Langue
anglais
Résumé
The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
Mots-clé
Aedes/genetics, Aedes/immunology, Aedes/microbiology, Aedes/parasitology, Animals, Anopheles gambiae/genetics, Anopheles gambiae/metabolism, Anopheles gambiae/microbiology, Anopheles gambiae/parasitology, Arboviruses/immunology, Arboviruses/pathogenicity, Arboviruses/physiology, Bacteria/immunology, Bacteria/pathogenicity, Biological Evolution, Culex/genetics, Culex/immunology, Culex/microbiology, Culex/parasitology, Ecosystem, Filarioidea/immunology, Filarioidea/pathogenicity, Filarioidea/physiology, Gene Expression Profiling, Gene Expression Regulation, Genes, Insect, Host-Pathogen Interactions, Immunity, Innate/genetics, Insect Vectors/genetics, Insect Vectors/immunology, Insect Vectors/microbiology, Insect Vectors/parasitology, Oligonucleotide Array Sequence Analysis, Phylogeny, RNA Interference, Transcription, Genetic, West Nile virus/immunology, West Nile virus/pathogenicity, West Nile virus/physiology
Pubmed
Web of science
Création de la notice
20/09/2017 10:11
Dernière modification de la notice
03/01/2020 18:15
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