Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

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Version: Final published version
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Serval ID
serval:BIB_C5DF47ED60E0
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Title
Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.
Journal
Science
Author(s)
Bartholomay L.C., Waterhouse R.M., Mayhew G.F., Campbell C.L., Michel K., Zou Z., Ramirez J.L., Das S., Alvarez K., Arensburger P., Bryant B., Chapman S.B., Dong Y., Erickson S.M., Karunaratne S.H., Kokoza V., Kodira C.D., Pignatelli P., Shin S.W., Vanlandingham D.L., Atkinson P.W., Birren B., Christophides G.K., Clem R.J., Hemingway J., Higgs S., Megy K., Ranson H., Zdobnov E.M., Raikhel A.S., Christensen B.M., Dimopoulos G., Muskavitch M.A.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
330
Number
6000
Pages
88-90
Language
english
Abstract
The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
Keywords
Aedes/genetics, Aedes/immunology, Aedes/microbiology, Aedes/parasitology, Animals, Anopheles gambiae/genetics, Anopheles gambiae/metabolism, Anopheles gambiae/microbiology, Anopheles gambiae/parasitology, Arboviruses/immunology, Arboviruses/pathogenicity, Arboviruses/physiology, Bacteria/immunology, Bacteria/pathogenicity, Biological Evolution, Culex/genetics, Culex/immunology, Culex/microbiology, Culex/parasitology, Ecosystem, Filarioidea/immunology, Filarioidea/pathogenicity, Filarioidea/physiology, Gene Expression Profiling, Gene Expression Regulation, Genes, Insect, Host-Pathogen Interactions, Immunity, Innate/genetics, Insect Vectors/genetics, Insect Vectors/immunology, Insect Vectors/microbiology, Insect Vectors/parasitology, Oligonucleotide Array Sequence Analysis, Phylogeny, RNA Interference, Transcription, Genetic, West Nile virus/immunology, West Nile virus/pathogenicity, West Nile virus/physiology
Pubmed
Web of science
Create date
20/09/2017 10:11
Last modification date
03/01/2020 18:15
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