Presence of genetic alterations in microdissected stroma of human colon and breast cancers.

Détails

ID Serval
serval:BIB_C4853F13E37B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Presence of genetic alterations in microdissected stroma of human colon and breast cancers.
Périodique
Journal of Molecular Medicine
Auteur(s)
Wernert N., Löcherbach C., Wellmann A., Behrens P., Hügel A.
ISSN
0946-2716
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
78
Numéro
7
Pages
B30
Langue
anglais
Notes
Publication types: Journal Article
Résumé
We show by laser-assisted microdissection that frequent genetic alterations in non-hereditary invasive human colon and breast cancers (loss of heterozygosity and TP53 mutations) occur not only in the neoplastic epithelial cells, but also in the adjacent fibroblastic tumor stroma and that both components can share clonal features. Tumor cell-mesenchyme transitions are among the possible explanations for these findings.
Mots-clé
Breast Neoplasms/genetics, Colonic Neoplasms/genetics, Dissection, Fibroblasts/metabolism, Genes, p53/genetics, Humans, Lasers, Loss of Heterozygosity, Microsatellite Repeats, Microscopy, Confocal, Mutation
Pubmed
Web of science
Création de la notice
27/02/2008 16:48
Dernière modification de la notice
20/08/2019 15:39
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