Presence of genetic alterations in microdissected stroma of human colon and breast cancers.

Details

Serval ID
serval:BIB_C4853F13E37B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Presence of genetic alterations in microdissected stroma of human colon and breast cancers.
Journal
Journal of Molecular Medicine
Author(s)
Wernert N., Löcherbach C., Wellmann A., Behrens P., Hügel A.
ISSN
0946-2716
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
78
Number
7
Pages
B30
Language
english
Notes
Publication types: Journal Article
Abstract
We show by laser-assisted microdissection that frequent genetic alterations in non-hereditary invasive human colon and breast cancers (loss of heterozygosity and TP53 mutations) occur not only in the neoplastic epithelial cells, but also in the adjacent fibroblastic tumor stroma and that both components can share clonal features. Tumor cell-mesenchyme transitions are among the possible explanations for these findings.
Keywords
Breast Neoplasms/genetics, Colonic Neoplasms/genetics, Dissection, Fibroblasts/metabolism, Genes, p53/genetics, Humans, Lasers, Loss of Heterozygosity, Microsatellite Repeats, Microscopy, Confocal, Mutation
Pubmed
Web of science
Create date
27/02/2008 16:48
Last modification date
20/08/2019 15:39
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