Subretinal mononuclear phagocyte accumulation on drusen in early age related macular degeneration

Détails

ID Serval
serval:BIB_C3440E531A6C
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Subretinal mononuclear phagocyte accumulation on drusen in early age related macular degeneration
Titre de la conférence
2018 ARVO Annual Meeting.
Auteur⸱e⸱s
Eandi CM, Pâques M, Guillonneau X, Sennlaub F
Organisation
2018 ARVO Annual Meeting, held in Honolulu, Hawaii,
Adresse
2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Statut éditorial
Publié
Date de publication
29/04/2018
Peer-reviewed
Oui
Volume
59
Pages
2436
Langue
anglais
Notes
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2436
Résumé
Purpose : Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people. The early form is characterized by the presence of big subretinal deposits, named drusen. While small (hard) drusen are associated with age but not with AMD, sizeable drusen are an important risk factor to develop late stage AMD, characterized by neovascularization (wet AMD) and photoreceptor and retina pigment epithelium (RPE) atrophy (geographic atrophy, GA). Others and we have previously demonstrated that late AMD is characterized by the infiltration of pathogenic mononuclear phagocytes.
To evaluate the presence of subretinal mononuclear phagocytes in human donor eyes with and without different sized drusen.
Methods : Three retina samples from macular and mid periphery from six donors were dissected stained by immunohistochemistryfor the MP-marker Iba-1. MPs were counted on whole RPE flatmounts..
Results : Subretinal Iba-1+ MPs are absent in healthy age-matched control donors, seldom present in donors with small drusen (< 63 µ) not associated with AMD, but their number was significantly increased on the RPE overlaying large drusen (> 125 µ).
Conclusions : Our experiments demonstrated MPs infiltrate the subretinal space in eyes with large drusen, associated with AMD, but not in eyes with small drusen. These findings show that subretinal MP infiltration is associated with large Drusen, an important risk factor for the development of late AMD.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Création de la notice
01/07/2021 12:35
Dernière modification de la notice
09/07/2021 6:37
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