Subretinal mononuclear phagocyte accumulation on drusen in early age related macular degeneration

Details

Serval ID
serval:BIB_C3440E531A6C
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Title
Subretinal mononuclear phagocyte accumulation on drusen in early age related macular degeneration
Title of the conference
2018 ARVO Annual Meeting.
Author(s)
Eandi CM, Pâques M, Guillonneau X, Sennlaub F
Organization
2018 ARVO Annual Meeting, held in Honolulu, Hawaii,
Address
2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
Publication state
Published
Issued date
29/04/2018
Peer-reviewed
Oui
Volume
59
Pages
2436
Language
english
Notes
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2436
Abstract
Purpose : Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people. The early form is characterized by the presence of big subretinal deposits, named drusen. While small (hard) drusen are associated with age but not with AMD, sizeable drusen are an important risk factor to develop late stage AMD, characterized by neovascularization (wet AMD) and photoreceptor and retina pigment epithelium (RPE) atrophy (geographic atrophy, GA). Others and we have previously demonstrated that late AMD is characterized by the infiltration of pathogenic mononuclear phagocytes.
To evaluate the presence of subretinal mononuclear phagocytes in human donor eyes with and without different sized drusen.
Methods : Three retina samples from macular and mid periphery from six donors were dissected stained by immunohistochemistryfor the MP-marker Iba-1. MPs were counted on whole RPE flatmounts..
Results : Subretinal Iba-1+ MPs are absent in healthy age-matched control donors, seldom present in donors with small drusen (< 63 µ) not associated with AMD, but their number was significantly increased on the RPE overlaying large drusen (> 125 µ).
Conclusions : Our experiments demonstrated MPs infiltrate the subretinal space in eyes with large drusen, associated with AMD, but not in eyes with small drusen. These findings show that subretinal MP infiltration is associated with large Drusen, an important risk factor for the development of late AMD.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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01/07/2021 12:35
Last modification date
09/07/2021 6:37
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