Autophagic cell death exists.
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_C163111DBBBF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
Autophagic cell death exists.
Périodique
Autophagy
ISSN
1554-8635 (Electronic)
ISSN-L
1554-8627
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
8
Numéro
6
Pages
867-869
Langue
anglais
Résumé
The term autophagic cell death (ACD) initially referred to cell death with greatly enhanced autophagy, but is increasingly used to imply a death-mediating role of autophagy, as shown by a protective effect of autophagy inhibition. In addition, many authors require that autophagic cell death must not involve apoptosis or necrosis. Adopting these new and restrictive criteria, and emphasizing their own failure to protect human osteosarcoma cells by autophagy inhibition, the authors of a recent Editor's Corner article in this journal argued for the extreme rarity or nonexistence of autophagic cell death. We here maintain that, even with the more stringent recent criteria, autophagic cell death exists in several situations, some of which were ignored by the Editor's Corner authors. We reject their additional criterion that the autophagy in ACD must be the agent of ultimate cell dismantlement. And we argue that rapidly dividing mammalian cells such as cancer cells are not the most likely situation for finding pure ACD.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/09/2012 19:22
Dernière modification de la notice
20/08/2019 16:36