Autophagic cell death exists.
Details
State: Public
Version: author
Serval ID
serval:BIB_C163111DBBBF
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Autophagic cell death exists.
Journal
Autophagy
ISSN
1554-8635 (Electronic)
ISSN-L
1554-8627
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
8
Number
6
Pages
867-869
Language
english
Abstract
The term autophagic cell death (ACD) initially referred to cell death with greatly enhanced autophagy, but is increasingly used to imply a death-mediating role of autophagy, as shown by a protective effect of autophagy inhibition. In addition, many authors require that autophagic cell death must not involve apoptosis or necrosis. Adopting these new and restrictive criteria, and emphasizing their own failure to protect human osteosarcoma cells by autophagy inhibition, the authors of a recent Editor's Corner article in this journal argued for the extreme rarity or nonexistence of autophagic cell death. We here maintain that, even with the more stringent recent criteria, autophagic cell death exists in several situations, some of which were ignored by the Editor's Corner authors. We reject their additional criterion that the autophagy in ACD must be the agent of ultimate cell dismantlement. And we argue that rapidly dividing mammalian cells such as cancer cells are not the most likely situation for finding pure ACD.
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2012 19:22
Last modification date
20/08/2019 16:36