Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes.

Détails

ID Serval
serval:BIB_BE2D29F4CA28
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes.
Périodique
La Ricerca in Clinica e in Laboratorio
Auteur(s)
Corradin G., Chesnut R.W., Grey H.M.
ISSN
0390-5748 (Print)
ISSN-L
0390-5748
Statut éditorial
Publié
Date de publication
1979
Volume
9
Numéro
4
Pages
311-318
Langue
anglais
Résumé
Evidence is presented which supports the hypothesis of protein degradation taking place in macrophages as a part of the presentation of antigen to T lymphocytes. It is postulated that the ability of T cells to recognize both native and denatured forms of the same protein is dependent upon degradation of both forms of the protein to yield the same peptides and thus results in the stimulation of identical subsets of T cells. The occasional observation of a lack of cross-reactivity could result if the native antigen is particularly resistant to the denaturing conditions found within macrophages.
Mots-clé
Antibody Formation, Antigen-Antibody Reactions, Antigens, Cell Division, Cross Reactions, Isoantigens, Macrophages, Mitogens, Protein Denaturation, T-Lymphocytes/immunology
Pubmed
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:32
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