Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes.

Details

Serval ID
serval:BIB_BE2D29F4CA28
Type
Article: article from journal or magazin.
Collection
Publications
Title
Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes.
Journal
La Ricerca in Clinica e in Laboratorio
Author(s)
Corradin G., Chesnut R.W., Grey H.M.
ISSN
0390-5748 (Print)
ISSN-L
0390-5748
Publication state
Published
Issued date
1979
Volume
9
Number
4
Pages
311-318
Language
english
Abstract
Evidence is presented which supports the hypothesis of protein degradation taking place in macrophages as a part of the presentation of antigen to T lymphocytes. It is postulated that the ability of T cells to recognize both native and denatured forms of the same protein is dependent upon degradation of both forms of the protein to yield the same peptides and thus results in the stimulation of identical subsets of T cells. The occasional observation of a lack of cross-reactivity could result if the native antigen is particularly resistant to the denaturing conditions found within macrophages.
Keywords
Antibody Formation, Antigen-Antibody Reactions, Antigens, Cell Division, Cross Reactions, Isoantigens, Macrophages, Mitogens, Protein Denaturation, T-Lymphocytes/immunology
Pubmed
Create date
24/01/2008 14:55
Last modification date
20/08/2019 15:32
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