Stored red blood cells: a changing universe waiting for its map(s).

Détails

ID Serval
serval:BIB_BD8058AAC434
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Stored red blood cells: a changing universe waiting for its map(s).
Périodique
Journal of Proteomics
Auteur(s)
Lion N., Crettaz D., Rubin O., Tissot J.D.
ISSN
1876-7737[electronic]
Statut éditorial
Publié
Date de publication
2010
Volume
73
Numéro
3
Pages
374-385
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The availability of stored red blood cells (RBCs) for transfusion remains an important aspect of the treatment of polytrauma, acute anemia or major bleedings. RBCs are prepared by blood banks from whole blood donations and stored in the cold in additive solutions for typically six weeks. These far from physiological storage conditions result in the so-called red cell storage lesion that is of importance both to blood bankers and to clinical practitioners. Here we review the current state of knowledge about the red cell storage lesion from a proteomic perspective. In particular, we describe the current models accounting for RBC aging and response to lethal stresses, review the published proteomic studies carried out to uncover the molecular basis of the RBC storage lesion, and conclude by suggesting a few possible proteomic studies that would provide further knowledge of the molecular alterations carried by RBCs stored in the cold for six weeks.
Mots-clé
Blood Preservation/methods, Blood Specimen Collection/methods, Blood Specimen Collection/standards, Cell Aging/physiology, Erythrocyte Transfusion/adverse effects, Erythrocyte Transfusion/standards, Erythrocytes, Humans, Models, Biological, Proteomics/methods, Proteomics/standards
Pubmed
Web of science
Création de la notice
04/11/2010 16:28
Dernière modification de la notice
20/08/2019 15:31
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