Venlafaxine versus applied relaxation for generalized anxiety disorder: a randomized controlled study on clinical and electrophysiological outcomes.

Détails

ID Serval
serval:BIB_BC755635C7BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Venlafaxine versus applied relaxation for generalized anxiety disorder: a randomized controlled study on clinical and electrophysiological outcomes.
Périodique
Psychiatric Quarterly
Auteur⸱e⸱s
Zullino D., Chatton A., Fresard E., Stankovic M., Bondolfi G., Borgeat F., Khazaal Y.
ISSN
1573-6709 (Electronic)
ISSN-L
0033-2720
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
86
Numéro
1
Pages
69-82
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Some components of generalized anxiety disorder, such as physical symptoms, are thought to reflect autonomic nervous system arousal. This study primarily assessed the relationships between psychophysiological and clinical measures using venlafaxine extended release or applied relaxation, and secondarily, the impact of combination treatment in patients not remitting after 8 weeks. Fifty-eight patients were randomly assigned to 8 weeks of treatment with either venlafaxine or applied relaxation (Phase I). Non-remitted patients received combination treatment for an additional 8 weeks (Phase II). Assessments included the Hamilton Anxiety Scale (HAM-A), Beck Depression Inventory, Penn State Worry Questionnaire and the Stroop Color-Word Task coupled with electrophysiological measures (skin conductance and frontalis electromyography (EMG)). In Phase 1, a time effect was found for the clinical and skin conductance measures. Thirteen patients from each group were in remission. In Phase 2, seven additional patients remitted. Baseline psychophysiological measures were not associated with baseline clinical variables or with clinical outcomes. Independently of treatment allocation, a reduction in frontal EMG values at week 4 was significantly associated with a decrease in HAM-A scores at week 8. At week 4, responders from the applied relaxation group had lower electrophysiological activity than the venlafaxine group. Baseline psychophysiological measures were not linked with clinical measures at study inclusion or with treatment response. Frontal EMG response at week 4 is a possible predictor of treatment response. Treatment combination enhances treatment response after initial failure.
Pubmed
Web of science
Création de la notice
18/04/2015 12:30
Dernière modification de la notice
19/01/2023 6:53
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