Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_BA4CF7B58271
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.
Périodique
Cell metabolism
Auteur⸱e⸱s
Greggio C., Jha P., Kulkarni S.S., Lagarrigue S., Broskey N.T., Boutant M., Wang X., Conde Alonso S., Ofori E., Auwerx J., Cantó C., Amati F.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
07/02/2017
Peer-reviewed
Oui
Volume
25
Numéro
2
Pages
301-311
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Résumé
Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 months of exercise training on skeletal muscle mitochondria electron transport chain complexes and supercomplexes in 26 healthy, sedentary older adults. Exercise differentially modulated respiratory complexes. Complex I was the most upregulated complex and not stoichiometrically associated to the other complexes. In contrast to the other complexes, complex I was almost exclusively found assembled in supercomplexes in muscle mitochondria. Overall, supercomplex content was increased after exercise. In particular, complexes I, III, and IV were redistributed to supercomplexes in the form of I+III2+IV. Taken together, our results provide the first evidence that exercise affects the stoichiometry of supercomplex formation in humans and thus reveal a novel adaptive mechanism for increased energy demand.
Mots-clé
Adiposity, Aged, Aging/metabolism, Cell Respiration, Electron Transport Chain Complex Proteins/metabolism, Exercise/physiology, Female, Humans, Male, Middle Aged, Muscle, Skeletal/physiology, Oxygen/metabolism, aging, electron transport chain, endurance training, exercise intervention, human, mitochondria, pre-/post-design, respiratory complex, skeletal muscle, supercomplex
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Carrières / PZ00P3-149398
Fonds national suisse / Projets / 320030_170062
Fonds national suisse / Carrières / PZ00P3-126339
Création de la notice
06/12/2016 18:07
Dernière modification de la notice
07/03/2024 7:13
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