Fastidious intracellular bacteria as causal agents of community-acquired pneumonia.

Détails

ID Serval
serval:BIB_BA0920F22E87
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fastidious intracellular bacteria as causal agents of community-acquired pneumonia.
Périodique
Expert review of anti-infective therapy
Auteur(s)
Lamoth F., Greub G.
ISSN
1744-8336 (Electronic)
ISSN-L
1478-7210
Statut éditorial
Publié
Date de publication
07/2010
Peer-reviewed
Oui
Volume
8
Numéro
7
Pages
775-790
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Intracellular bacteria are common causes of community-acquired pneumonia that grow poorly or not at all on standard culture media and do not respond to beta-lactam antibiotic therapy. Apart from well-established agents of pneumonia such as Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia psittaci and Coxiella burnetii, some new emerging pathogens have recently been recognized, mainly Parachlamydia acanthamoebae and Simkania negevensis, two Chlamydia-related bacteria. Most of them are causes of benign and self-limited infections. However, they may cause severe pneumonia in some cases (i.e., Legionnaires' disease) and they may cause outbreaks representing a public health problem deserving prompt recognition and appropriate therapy. Although extrapulmonary manifestations are often present, no clinical features allow them to be distinguished from classical bacterial agents of pneumonia such as Streptococcus pneumoniae. Thus, specific molecular diagnostic tools are very helpful for early recognition of the offending bacteria, whereas serology often only allows retrospective or late diagnosis. Macrolides remain the best empirical treatment of intracellular respiratory pathogens, although some observational studies suggest that quinolones may be superior for the treatment of legionellosis.
Mots-clé
Bacteria/classification, Bacteria/drug effects, Bacteria/isolation & purification, Community-Acquired Infections/diagnosis, Community-Acquired Infections/drug therapy, Community-Acquired Infections/microbiology, Humans, Macrolides/therapeutic use, Pneumonia, Bacterial/diagnosis, Pneumonia, Bacterial/drug therapy, Pneumonia, Bacterial/microbiology, Quinolones/therapeutic use
Pubmed
Web of science
Création de la notice
03/10/2019 16:13
Dernière modification de la notice
29/09/2021 5:42
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