Fastidious intracellular bacteria as causal agents of community-acquired pneumonia.

Details

Serval ID
serval:BIB_BA0920F22E87
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fastidious intracellular bacteria as causal agents of community-acquired pneumonia.
Journal
Expert review of anti-infective therapy
Author(s)
Lamoth F., Greub G.
ISSN
1744-8336 (Electronic)
ISSN-L
1478-7210
Publication state
Published
Issued date
07/2010
Peer-reviewed
Oui
Volume
8
Number
7
Pages
775-790
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Intracellular bacteria are common causes of community-acquired pneumonia that grow poorly or not at all on standard culture media and do not respond to beta-lactam antibiotic therapy. Apart from well-established agents of pneumonia such as Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia psittaci and Coxiella burnetii, some new emerging pathogens have recently been recognized, mainly Parachlamydia acanthamoebae and Simkania negevensis, two Chlamydia-related bacteria. Most of them are causes of benign and self-limited infections. However, they may cause severe pneumonia in some cases (i.e., Legionnaires' disease) and they may cause outbreaks representing a public health problem deserving prompt recognition and appropriate therapy. Although extrapulmonary manifestations are often present, no clinical features allow them to be distinguished from classical bacterial agents of pneumonia such as Streptococcus pneumoniae. Thus, specific molecular diagnostic tools are very helpful for early recognition of the offending bacteria, whereas serology often only allows retrospective or late diagnosis. Macrolides remain the best empirical treatment of intracellular respiratory pathogens, although some observational studies suggest that quinolones may be superior for the treatment of legionellosis.
Keywords
Bacteria/classification, Bacteria/drug effects, Bacteria/isolation & purification, Community-Acquired Infections/diagnosis, Community-Acquired Infections/drug therapy, Community-Acquired Infections/microbiology, Humans, Macrolides/therapeutic use, Pneumonia, Bacterial/diagnosis, Pneumonia, Bacterial/drug therapy, Pneumonia, Bacterial/microbiology, Quinolones/therapeutic use
Pubmed
Web of science
Create date
03/10/2019 16:13
Last modification date
04/10/2019 5:26
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