Challenges in High-grade Neuroendocrine Neoplasms and Mixed Neuroendocrine/Non-neuroendocrine Neoplasms.

Détails

Ressource 1Télécharger: larosa.pdf (3163.64 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B897B1EFBE42
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Challenges in High-grade Neuroendocrine Neoplasms and Mixed Neuroendocrine/Non-neuroendocrine Neoplasms.
Périodique
Endocrine pathology
Auteur⸱e⸱s
La Rosa S.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Statut éditorial
Publié
Date de publication
06/2021
Peer-reviewed
Oui
Volume
32
Numéro
2
Pages
245-257
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The growth in knowledge of the pathogenesis, molecular background, and immunohistochemical profile of neuroendocrine neoplasms (NENs) has led not only to an increased awareness of these diseases but also to several changes of the nomenclature. In particular, the concept and terminology of high-grade (grade 3) NENs and mixed neoplasms have changed considerably over the last 20 years, creating some confusion among pathologists and clinicians. The aim of this review is to elucidate the diagnostic criteria, including the most important differential diagnoses of high-grade NENs and mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs). The role of the Ki67 labelling index and morphology, used to define grade 3 NENs of the digestive system and lungs, is also discussed. The evolution of the concepts and terminology of MiNENs is revised, including the most important differential diagnoses.
Mots-clé
Diagnosis, High grade, Ki67, MiNEN, Neuroendocrine carcinoma, Neuroendocrine tumor
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/04/2021 13:18
Dernière modification de la notice
15/05/2021 6:31
Données d'usage