Challenges in High-grade Neuroendocrine Neoplasms and Mixed Neuroendocrine/Non-neuroendocrine Neoplasms.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_B897B1EFBE42
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Challenges in High-grade Neuroendocrine Neoplasms and Mixed Neuroendocrine/Non-neuroendocrine Neoplasms.
Journal
Endocrine pathology
Author(s)
La Rosa S.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
32
Number
2
Pages
245-257
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The growth in knowledge of the pathogenesis, molecular background, and immunohistochemical profile of neuroendocrine neoplasms (NENs) has led not only to an increased awareness of these diseases but also to several changes of the nomenclature. In particular, the concept and terminology of high-grade (grade 3) NENs and mixed neoplasms have changed considerably over the last 20 years, creating some confusion among pathologists and clinicians. The aim of this review is to elucidate the diagnostic criteria, including the most important differential diagnoses of high-grade NENs and mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs). The role of the Ki67 labelling index and morphology, used to define grade 3 NENs of the digestive system and lungs, is also discussed. The evolution of the concepts and terminology of MiNENs is revised, including the most important differential diagnoses.
Keywords
Diagnosis, High grade, Ki67, MiNEN, Neuroendocrine carcinoma, Neuroendocrine tumor
Pubmed
Web of science
Open Access
Yes
Create date
01/04/2021 13:18
Last modification date
15/05/2021 6:31
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