Comparison of local intravascular drug-delivery catheter systems.

Détails

ID Serval
serval:BIB_B88351944B17
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of local intravascular drug-delivery catheter systems.
Périodique
American Heart Journal
Auteur⸱e⸱s
Gonschior P., Pahl C., Huehns T.Y., Gerheuser F., Erdemci A., Larisch K., Dellian M., Deil S., Goetz A.E., Lehr H.A., Hofling B.
ISSN
0002-8703 (Print)
ISSN-L
0002-8703
Statut éditorial
Publié
Date de publication
1995
Volume
130
Numéro
6
Pages
1174-1181
Langue
anglais
Résumé
Systemic and local delivery of the photosensitive drug Photofrin polyporphyrin was investigated in normal porcine arteries (n = 192). A macroporous balloon and a novel needle injection catheter were used for local drug delivery and compared with systemic delivery. Fluorescence microscopy combined with digital image analysis was used to quantify the drug-related fluorescence. Systemic delivery showed a maximum in the intima at 4 hours. Application with the porous balloon revealed maximum indicator-related fluorescence intensity in the intima after 5 minutes; delivery with the needle injection catheter resulted in a several-fold enhanced maximum in adventitia after 30 minutes compared with the maximum achieved with either systemic injection or porous balloon application. After 21 days fluorescence was detectable in arteries treated with the new needle injection catheter. Local drug delivery is feasible with either system, but prolonged delivery was achieved only with the needle injection catheter.
Mots-clé
Animals, Balloon Dilation, Catheterization/instrumentation, Drug Delivery Systems, Feasibility Studies, Female, Male, Photosensitizing Agents/administration & dosage, Porphyrins/administration & dosage, Swine
Pubmed
Web of science
Création de la notice
25/11/2011 20:26
Dernière modification de la notice
20/08/2019 16:26
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