Signaling networks in B cell development and related therapeutic strategies.

Détails

ID Serval
serval:BIB_B8683F218609
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Signaling networks in B cell development and related therapeutic strategies.
Périodique
Journal of leukocyte biology
Auteur⸱e⸱s
Ren A., Sun J., Yin W., Westerberg L.S., Miller H., Lee P., Candotti F., Guan F., Lei J., Gong Q., Chen Y., Liu C.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Statut éditorial
Publié
Date de publication
04/2022
Peer-reviewed
Oui
Volume
111
Numéro
4
Pages
877-891
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.
Mots-clé
B-Lymphocyte Subsets, B-Lymphocytes, Immunity, Humoral, Lymphocyte Activation, Receptors, Antigen, B-Cell, Signal Transduction, B cell development, BAFFR, BCR, IL-7R, pre-BCR, signal, therapeutic strategy
Pubmed
Web of science
Création de la notice
27/09/2021 12:36
Dernière modification de la notice
27/05/2022 17:22
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