Signaling networks in B cell development and related therapeutic strategies.

Details

Serval ID
serval:BIB_B8683F218609
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Signaling networks in B cell development and related therapeutic strategies.
Journal
Journal of leukocyte biology
Author(s)
Ren A., Sun J., Yin W., Westerberg L.S., Miller H., Lee P., Candotti F., Guan F., Lei J., Gong Q., Chen Y., Liu C.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.
Keywords
B cell development, BAFFR, BCR, IL-7R, pre-BCR, signal, therapeutic strategy
Pubmed
Web of science
Create date
27/09/2021 11:36
Last modification date
16/10/2021 5:35
Usage data