Efavirenz intoxication due to a new CYP2B6 constellation.
Détails
ID Serval
serval:BIB_B791CC3A33EA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efavirenz intoxication due to a new CYP2B6 constellation.
Périodique
Antiviral Therapy
ISSN
2040-2058 (Electronic)
ISSN-L
1359-6535
Statut éditorial
Publié
Date de publication
2013
Volume
18
Numéro
5
Pages
739-743
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.
Pubmed
Web of science
Création de la notice
17/02/2014 16:50
Dernière modification de la notice
20/08/2019 16:25
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