Efavirenz intoxication due to a new CYP2B6 constellation.

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Serval ID
serval:BIB_B791CC3A33EA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Efavirenz intoxication due to a new CYP2B6 constellation.
Journal
Antiviral Therapy
Author(s)
Anagnostopoulos A., Rotger M., Aouri M., Kuster S.P., Telenti A., Décosterd L.A., Günthard H.F.
ISSN
2040-2058 (Electronic)
ISSN-L
1359-6535
Publication state
Published
Issued date
2013
Volume
18
Number
5
Pages
739-743
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.
OAI-PMH
oai:serval.unil.ch:BIB_B791CC3A33EA
DOI
10.3851/IMP2571
Pubmed
23640958
Web of science
000329761700013
Create date
17/02/2014 16:50
Last modification date
20/08/2019 16:25
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