The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

Détails

Ressource 1Télécharger: serval:BIB_B625576C98E8.P001 (654.80 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_B625576C98E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The evolutionary conserved BER1 gene is involved in microtubule stability in yeast
Périodique
Current Genetics
Auteur(s)
Fiechter V., Cameroni E., Cerutti L., De V. C., Barral Y., Fankhauser C.
ISSN
0172-8083
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
53
Numéro
2
Pages
107-115
Langue
anglais
Résumé
In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Delta mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Delta mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins
Mots-clé
Acetylation , Arabidopsis , chemistry , Conserved Sequence , Evolution,Molecular , Fungal Proteins , Genes,Fungal , genetics , Genomics , Light , Microtubule-Associated Proteins , Mutation , physiology , Protein Processing,Post-Translational , Proteins , Switzerland , ultrastructure , Yeasts
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2009 23:13
Dernière modification de la notice
01/10/2019 7:19
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