The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

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Ressource 1Download: serval:BIB_B625576C98E8.P001 (654.80 [Ko])
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Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B625576C98E8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The evolutionary conserved BER1 gene is involved in microtubule stability in yeast
Journal
Current Genetics
Author(s)
Fiechter V., Cameroni E., Cerutti L., De V. C., Barral Y., Fankhauser C.
ISSN
0172-8083
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
53
Number
2
Pages
107-115
Language
english
Abstract
In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Delta mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Delta mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins
Keywords
Acetylation , Arabidopsis , chemistry , Conserved Sequence , Evolution,Molecular , Fungal Proteins , Genes,Fungal , genetics , Genomics , Light , Microtubule-Associated Proteins , Mutation , physiology , Protein Processing,Post-Translational , Proteins , Switzerland , ultrastructure , Yeasts
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 22:13
Last modification date
01/10/2019 6:19
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