Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.

Détails

ID Serval
serval:BIB_B5D9B19A134E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.
Périodique
Cell reports
Auteur⸱e⸱s
Ercolano G., Moretti A., Falquet M., Wyss T., Tran N.L., Senoner I., Marinoni M., Agosti M., Salvatore S., Jandus C., Trabanelli S.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
14/06/2022
Peer-reviewed
Oui
Volume
39
Numéro
11
Pages
110956
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-γ, paralleled by an expansion of ILC precursors (ILCPs). In the presence of the gliadin peptides p31-43 and pα-9, ILCPs from CD patients increase transglutaminase 2 (TG2) expression, produce IL-18 and IFN-γ, and stimulate CD4 <sup>+</sup> T lymphocytes. IFN-γ is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-γ and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-γ production.
Mots-clé
Celiac Disease/immunology, Celiac Disease/metabolism, Gliadin/metabolism, Gliadin/pharmacology, Humans, Immunity, Innate, Interleukin-12 Subunit p40/metabolism, Interleukin-18/metabolism, Intestinal Mucosa/metabolism, Lymphocytes/metabolism, Vitamin D/metabolism, Vitamin D/pharmacology, CP: Immunology, IFN-γ, IL-12, IL-18, ILCPs, ILCs, celiac disease, extraintestinal symptoms, gliadin, gluten peptides, innate lymphoid cells, vitamin D
Pubmed
Open Access
Oui
Création de la notice
05/07/2022 11:35
Dernière modification de la notice
15/07/2022 5:36
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