Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.

Details

Serval ID
serval:BIB_B5D9B19A134E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.
Journal
Cell reports
Author(s)
Ercolano G., Moretti A., Falquet M., Wyss T., Tran N.L., Senoner I., Marinoni M., Agosti M., Salvatore S., Jandus C., Trabanelli S.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
14/06/2022
Peer-reviewed
Oui
Volume
39
Number
11
Pages
110956
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-γ, paralleled by an expansion of ILC precursors (ILCPs). In the presence of the gliadin peptides p31-43 and pα-9, ILCPs from CD patients increase transglutaminase 2 (TG2) expression, produce IL-18 and IFN-γ, and stimulate CD4 <sup>+</sup> T lymphocytes. IFN-γ is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-γ and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-γ production.
Keywords
Celiac Disease/immunology, Celiac Disease/metabolism, Gliadin/metabolism, Gliadin/pharmacology, Humans, Immunity, Innate, Interleukin-12 Subunit p40/metabolism, Interleukin-18/metabolism, Intestinal Mucosa/metabolism, Lymphocytes/metabolism, Vitamin D/metabolism, Vitamin D/pharmacology, CP: Immunology, IFN-γ, IL-12, IL-18, ILCPs, ILCs, celiac disease, extraintestinal symptoms, gliadin, gluten peptides, innate lymphoid cells, vitamin D
Pubmed
Open Access
Yes
Create date
05/07/2022 12:35
Last modification date
15/07/2022 6:36
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