Vasopressin synthesis by the magnocellular neurons is different in the supraoptic nucleus and in the paraventricular nucleus in human and experimental septic shock.

Détails

ID Serval
serval:BIB_B5775F38BDA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vasopressin synthesis by the magnocellular neurons is different in the supraoptic nucleus and in the paraventricular nucleus in human and experimental septic shock.
Périodique
Brain Pathology (zurich, Switzerland)
Auteur⸱e⸱s
Sonneville R., Guidoux C., Barrett L., Viltart O., Mattot V., Polito A., Siami S., de la Grandmaison G.L., Blanchard A., Singer M., Annane D., Gray F., Brouland J.P., Sharshar T.
ISSN
1750-3639 (Electronic)
ISSN-L
1015-6305
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
20
Numéro
3
Pages
613-622
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Impaired arginine vasopressin (AVP) synthesis and release by the neurohypophyseal system, which includes the neurohypophysis and magnocellular neurons of the paraventricular and supraoptic nuclei, have been postulated in septic shock, but changes in this system have never been assessed in human septic shock, and only partially experimentally. We investigated AVP synthesis and release by the neurohypophyseal system in 9 patients who died from septic shock and 10 controls, and in 20 rats with fecal peritonitis-induced sepsis and 8 sham-operation controls. Ten rats died spontaneously from septic shock, and the others were sacrificed. In patients with septic shock, as in rats that died spontaneously following sepsis induction, AVP immunohistochemical expression was decreased in the neurohypophysis and supraoptic magnocellular neurons, whereas it was increased in the paraventricular magnocellular neurons. No significant change was observed in AVP messenger RiboNucleic Acid (mRNA) expression assessed by in situ hybridization in either paraventricular or supraoptic magnocellular cells. This study shows that both in human and experimental septic shock, AVP posttranscriptional synthesis and transport are differently modified in the magnocellular neurons of the supraoptic and paraventricular nuclei. This may account for the inappropriate AVP release in septic shock and suggests that distinct pathogenic mechanisms operate in these nuclei.
Mots-clé
Adult, Aged, Aged, 80 and over, Animals, Arginine Vasopressin/biosynthesis, Disease Models, Animal, Female, Humans, Male, Middle Aged, Neurons/metabolism, Neurons/secretion, Paraventricular Hypothalamic Nucleus/metabolism, Paraventricular Hypothalamic Nucleus/secretion, Rats, Rats, Wistar, Shock, Septic/metabolism, Supraoptic Nucleus/metabolism, Supraoptic Nucleus/secretion
Pubmed
Web of science
Création de la notice
13/10/2015 9:59
Dernière modification de la notice
20/08/2019 15:23
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