Opioides intrathecaux dans le traitement des douleurs chroniques: mecanismes d'action et aspects cliniques. [Spinal opioids: mechanisms of action and chronic pain management]

Détails

ID Serval
serval:BIB_B48D6A754DE4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Opioides intrathecaux dans le traitement des douleurs chroniques: mecanismes d'action et aspects cliniques. [Spinal opioids: mechanisms of action and chronic pain management]
Périodique
Revue Médicale Suisse
Auteur(s)
Decosterd  I., Beggah  A. T., Durrer  A., Buchser  E.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
2
Numéro
71
Pages
1636-8, 1640
Notes
English Abstract
Journal Article
Review --- Old month value: Jun 21
Résumé
The efficacy of spinal opioids is well known, the analgesia is potent and long lasting, due to the central localization of the opioid receptors. The analgesia is intimately related to the inhibition of the nociceptive signal in the spinal cord but side effects are mainly mediated by the activation of the mu opioid receptor in the brain and the brain stem. Only a limited number of controlled clinical studies compared systemic versus spinal administration of morphine in chronic pain patients, and the real benefit for the intrathecal route remains controversial. Implanted devices for a continuous intrathecal delivery of opioids should be prescribed only to patients with intractable chronic pain for which conventional methods were previously ineffective.
Mots-clé
Analgesics, Opioid/*pharmacology/*therapeutic use Chronic Disease Decision Making Humans Injections, Spinal Pain/*drug therapy
Pubmed
Création de la notice
28/01/2008 10:45
Dernière modification de la notice
20/08/2019 15:22
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