Opioides intrathecaux dans le traitement des douleurs chroniques: mecanismes d'action et aspects cliniques. [Spinal opioids: mechanisms of action and chronic pain management]

Details

Serval ID
serval:BIB_B48D6A754DE4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Opioides intrathecaux dans le traitement des douleurs chroniques: mecanismes d'action et aspects cliniques. [Spinal opioids: mechanisms of action and chronic pain management]
Journal
Revue Médicale Suisse
Author(s)
Decosterd  I., Beggah  A. T., Durrer  A., Buchser  E.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
06/2006
Volume
2
Number
71
Pages
1636-8, 1640
Notes
English Abstract
Journal Article
Review --- Old month value: Jun 21
Abstract
The efficacy of spinal opioids is well known, the analgesia is potent and long lasting, due to the central localization of the opioid receptors. The analgesia is intimately related to the inhibition of the nociceptive signal in the spinal cord but side effects are mainly mediated by the activation of the mu opioid receptor in the brain and the brain stem. Only a limited number of controlled clinical studies compared systemic versus spinal administration of morphine in chronic pain patients, and the real benefit for the intrathecal route remains controversial. Implanted devices for a continuous intrathecal delivery of opioids should be prescribed only to patients with intractable chronic pain for which conventional methods were previously ineffective.
Keywords
Analgesics, Opioid/*pharmacology/*therapeutic use Chronic Disease Decision Making Humans Injections, Spinal Pain/*drug therapy
Pubmed
Create date
28/01/2008 10:45
Last modification date
20/08/2019 15:22
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