Immunological lessons from genome-wide association studies of infections.

Détails

ID Serval
serval:BIB_B2F8837F7024
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Immunological lessons from genome-wide association studies of infections.
Périodique
Current opinion in immunology
Auteur⸱e⸱s
Thorball C.W., Fellay J., Borghesi A.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
10/2021
Peer-reviewed
Oui
Volume
72
Pages
87-93
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Over the past few years, genome-wide association studies (GWAS) have been increasingly applied to identify host genetic factors influencing clinical and laboratory traits related to immunity and infection, and to understand the interplay between the host and the microbial genomes. By screening large cohorts of individuals suffering from various infectious diseases, GWAS explored resistance against infection, natural history of the disease, development of life-threatening clinical signs, and innate and adaptive immune responses. These efforts provided fundamental insight on the role of major genes in the interindividual variability in the response to infection and on the mechanisms of the immune response against human pathogens both at the individual and population levels.
Mots-clé
Animals, Biomarkers, Disease Resistance/genetics, Disease Resistance/immunology, Disease Susceptibility/immunology, Genetic Predisposition to Disease, Genome-Wide Association Study, Host-Pathogen Interactions/genetics, Host-Pathogen Interactions/immunology, Humans, Immunity/genetics, Immunity/immunology, Infections/etiology
Pubmed
Web of science
Création de la notice
26/04/2021 8:40
Dernière modification de la notice
09/04/2022 5:33
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