Immunological lessons from genome-wide association studies of infections.

Details

Serval ID
serval:BIB_B2F8837F7024
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunological lessons from genome-wide association studies of infections.
Journal
Current opinion in immunology
Author(s)
Thorball C.W., Fellay J., Borghesi A.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Publication state
Published
Issued date
17/04/2021
Peer-reviewed
Oui
Volume
72
Pages
87-93
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Over the past few years, genome-wide association studies (GWAS) have been increasingly applied to identify host genetic factors influencing clinical and laboratory traits related to immunity and infection, and to understand the interplay between the host and the microbial genomes. By screening large cohorts of individuals suffering from various infectious diseases, GWAS explored resistance against infection, natural history of the disease, development of life-threatening clinical signs, and innate and adaptive immune responses. These efforts provided fundamental insight on the role of major genes in the interindividual variability in the response to infection and on the mechanisms of the immune response against human pathogens both at the individual and population levels.
Pubmed
Web of science
Create date
26/04/2021 8:40
Last modification date
09/10/2021 5:38
Usage data