Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptide.

Détails

ID Serval
serval:BIB_B2C29C4B47D4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptide.
Périodique
Journal of Hypertension. Supplement
Auteur(s)
Biollaz J., Nussberger J., Waeber B., Brunner H.R.
ISSN
0952-1178
Statut éditorial
Publié
Date de publication
1986
Volume
4
Numéro
2
Pages
S101-108
Langue
anglais
Résumé
The clinical pharmacology of a synthetic rat atrial natriuretic peptide (rANP) was evaluated in normal volunteers. During a dose-ranging study at 1-40 micrograms/min we observed a dose-dependent decrease in mean intra-arterial blood pressure, an acceleration of the heart rate and a transient increase in blood flow to the skin. During a 4-h constant-dose infusion at 0.5 and 5.0 micrograms/min, inulin clearance remained unchanged but there was a dose-related fall in paraaminohippurate (PAH) clearance and an increase in the filtration fraction. Urinary excretion of sodium, chloride and calcium increased in a dose-related fashion, but with the high dose the excretion curve had a bell-shape. No change in plasma renin activity, angiotensin II and aldosterone was observed during the rANP infusion despite the excretion of large amounts of sodium and a blood pressure reduction with the high dose. Indocyanine green clearance, a measure of hepatic blood flow, was significantly decreased by a 2-h rANP infusion at 1.0 microgram/min. In normal volunteers, therefore, rANP induced vasodilation and blood pressure reduction, a decrease in renal and hepatic blood flow and a natriuretic and transient diuretic effect without activation of the renin-angiotensin-aldosterone system.
Mots-clé
Animals, Atrial Natriuretic Factor, Blood Pressure, Calcium, Heart Rate, Hematocrit, Humans, Natriuresis, Osmolar Concentration, Peptide Fragments, Phosphates, Potassium, Rats, Renal Circulation, Time Factors
Pubmed
Web of science
Création de la notice
05/03/2008 16:40
Dernière modification de la notice
20/08/2019 15:21
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