Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptide.

Details

Serval ID
serval:BIB_B2C29C4B47D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptide.
Journal
Journal of Hypertension. Supplement
Author(s)
Biollaz J., Nussberger J., Waeber B., Brunner H.R.
ISSN
0952-1178
Publication state
Published
Issued date
1986
Volume
4
Number
2
Pages
S101-108
Language
english
Abstract
The clinical pharmacology of a synthetic rat atrial natriuretic peptide (rANP) was evaluated in normal volunteers. During a dose-ranging study at 1-40 micrograms/min we observed a dose-dependent decrease in mean intra-arterial blood pressure, an acceleration of the heart rate and a transient increase in blood flow to the skin. During a 4-h constant-dose infusion at 0.5 and 5.0 micrograms/min, inulin clearance remained unchanged but there was a dose-related fall in paraaminohippurate (PAH) clearance and an increase in the filtration fraction. Urinary excretion of sodium, chloride and calcium increased in a dose-related fashion, but with the high dose the excretion curve had a bell-shape. No change in plasma renin activity, angiotensin II and aldosterone was observed during the rANP infusion despite the excretion of large amounts of sodium and a blood pressure reduction with the high dose. Indocyanine green clearance, a measure of hepatic blood flow, was significantly decreased by a 2-h rANP infusion at 1.0 microgram/min. In normal volunteers, therefore, rANP induced vasodilation and blood pressure reduction, a decrease in renal and hepatic blood flow and a natriuretic and transient diuretic effect without activation of the renin-angiotensin-aldosterone system.
Keywords
Animals, Atrial Natriuretic Factor, Blood Pressure, Calcium, Heart Rate, Hematocrit, Humans, Natriuresis, Osmolar Concentration, Peptide Fragments, Phosphates, Potassium, Rats, Renal Circulation, Time Factors
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 15:21
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