Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma.

Détails

Ressource 1Télécharger: 31748560_BIB_B2ADA6C4E5AE.pdf (2688.91 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_B2ADA6C4E5AE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma.
Périodique
Scientific reports
Auteur(s)
Tsantoulis P., Delorenzi M., Bièche I., Vacher S., Mariani P., Cassoux N., Houy A., Stern M.H., Roman-Roman S., Dietrich P.Y., Roth A., Cacheux W.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
20/11/2019
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
17178
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Predicting the risk of liver metastasis can have important prognostic and therapeutic implications, given the availability of liver-directed therapy. Uveal melanoma has a striking predisposition for liver metastasis despite the absence of anatomical proximity. Understanding its biology may uncover factors promoting liver metastasis in other malignancies. We quantified gene expression by RNAseq in 76 uveal melanomas and combined with public data in a meta-analysis of 196 patients. The meta-analysis of uveal melanoma gene expression identified 63 genes which remained prognostic after adjustment for chromosome 3 status. Two genes, PTP4A3 and JPH1, were selected by L1-penalized regression and combined in a prognostic score. The score predicted liver-specific relapse in a public pan-cancer dataset and in two public colorectal cancer datasets. The score varied between colorectal consensus molecular subtypes (CMS), as did the risk of liver relapse, which was lowest in CMS1. Additional prospective validation was done by real-time PCR in 463 breast cancer patients. The score was significantly correlated with liver relapse in hormone receptor positive tumors. In conclusion, the expression of PTP4A3 and JPH1 correlates with risk of liver metastasis in colorectal cancer and breast cancer. The underlying biological mechanism is an interesting area for further research.
Pubmed
Open Access
Oui
Création de la notice
30/11/2019 12:38
Dernière modification de la notice
30/04/2021 6:14
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