Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.

Détails

ID Serval
serval:BIB_B22BBED5F512
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
Périodique
World Journal of Surgery
Auteur(s)
Grass F., Schäfer M., Cristaudi A., Berutto C., Aubert J.D., Gonzalez M., Demartines N., Ris H.B., Soccal P.M., Krueger T.
ISSN
1432-2323 (Electronic)
ISSN-L
0364-2313
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
39
Numéro
9
Pages
2274-2281
Langue
anglais
Résumé
BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences and impact of GI complications after lung transplantation and aimed to identify risk factors.
METHODS: Retrospective analysis of all 227 consecutively performed single- and double-lung transplantations at the University hospitals of Lausanne and Geneva was performed between January 1993 and December 2010. Logistic regressions were used to test the effect of potentially influencing variables on the binary outcomes overall, severe, and surgery-requiring complications, followed by a multiple logistic regression model.
RESULTS: Final analysis included 205 patients for the purpose of the present study, and 22 patients were excluded due to re-transplantation, multiorgan transplantation, or incomplete datasets. GI complications were observed in 127 patients (62 %). Gastro-esophageal reflux disease was the most commonly observed complication (22.9 %), followed by inflammatory or infectious colitis (20.5 %) and gastroparesis (10.7 %). Major GI complications (Dindo/Clavien III-V) were observed in 83 (40.5 %) patients and were fatal in 4 patients (2.0 %). Multivariate analysis identified double-lung transplantation (p = 0.012) and early (1993-1998) transplantation period (p = 0.008) as independent risk factors for developing major GI complications. Forty-three (21 %) patients required surgery such as colectomy, cholecystectomy, and fundoplication in 6.8, 6.3, and 3.9 % of the patients, respectively. Multivariate analysis identified Charlson comorbidity index of ≥3 as an independent risk factor for developing GI complications requiring surgery (p = 0.015).
CONCLUSION: GI complications after lung transplantation are common. Outcome was rather encouraging in the setting of our transplant center.
Pubmed
Web of science
Création de la notice
07/09/2015 14:18
Dernière modification de la notice
20/08/2019 15:20
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